Dr Chan Ching Wan

Senior Consultant & Breast Surgeon
MBChB (Edin), FRCS (Edin), FRCS (Glas), PhD (Bristol)

As our senior consultant, Dr Chan Ching Wan has a special interest in the formation of cancer, and how it can be inhibited and treated. Dr Chan is also an Assistant Professor at Yong Loo Lin School of Medicine, NUS, since 2009. Prior to joining Solis, she was the Cluster Sub-specialty Lead for Breast Services in Singapore’s National University Health System. Dr Chan was also the Tumour Programme Lead for Breast Oncology for National Cancer Institute Singapore.

Training and Qualifications

Dr Chan obtained her medical degree from the University of Edinburgh Medical School. Subsequently, Dr Chan completed both basic and advanced specialty training in general surgery at the Singapore General Hospital, and exited from the programme in 2007. She has been a fellow of the Royal College of Surgeons of Edinburgh, and a fellow of the Royal College of Physicians and Surgeons of Glasgow since 1999. In the midst of her surgery training, Dr Chan received an NMRC Totalisator Board Scholarship where she completed her PhD in Neuroendocrinology at the University of Bristol in 2004.

Awarded the HMDP Award and Skills Attachment Award

In 2008, Dr Chan received the Health Manpower Development Program (HMDP) Award as an oncoplastic Breast Fellow in Nottingham Breast Institute, UK. She is trained in the procedures of therapeutic mammoplasty, latissimus dorsi flap for partial and total breast reconstruction, implant reconstruction, contralateral symmetrisation surgery, and the transfer of fat for volume deficits and contour remodelling. Additionally, Dr Chan helped develop transitional studies aimed at various aspects of cancer diagnosis, detection, and treatment.

As she pursued her interests and education, she also received a Skills Attachment Award in contrast-enhanced digital mammography (team AMDA Award) in 2018.

Read Articles By Dr Chan Ching Wan
Medical Publications By Dr Chan Ching Wan

Optoacoustic characterization of breast conserving surgery specimens – A pilot study. PHOTOACOUSTICS, 19, 9 pages (2020)
G. Balasundaram, Goh, Y., Moothanchery. M, Attia, A., Lim, H.Q., Burton, N. C., Olivo, M., Chan, C.W.

Maintaining breast cancer care in the face of COVID-19. British Journal of Surgery, 107(10), 1245-1249 (2020)
Ng, C. W. Q., Tseng, M., Lim, J. S. J., & Chan, C. W.

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. NATURE COMMUNICATIONS, 11(1), 11 pages (2020)
Ho, W. K., Tan, M. M., Mavaddat, N., Tai, M. C., Mariapun, S., Li, J., Antoniou, A. C., Chan, C. W.

Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies. TRANSLATIONAL ONCOLOGY, 13(2), 254-261 (2020)
Goh, Y., Balasundaram, G., Moothanchery, M., Attia, A., Li, X., Lim, H. Q., Olivo, M., Chan, C. W.

Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution.. Nat Biomed Eng, 3(9), 684-694 (2019)
Sundah, N. R., Ho, N. R. Y., Lim, G. S., Natalia, A., Ding, X., Liu, Y., Shao, H., Chan, C. W.

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium. Molecular Genetics and Genomic Medicine, 7(6) (2019)
Ugai, T., Milne, R. L., Ito, H., Aronson, K. J., Bolla, M. K., Chan, T., Matsuo, K., Chan, C. W.

Investing in gender equity in health and biomedical research: a Singapore perspective. LANCET, 393(10171), E21-E22 (2019)
Yoong, J., Alonso, S., Chan, C. W., Clement, M. V., Lim, L. H. K., & Archuleta, S.

Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study. CLINICAL BREAST CANCER, 18(6), E1247-E1250 (2018)
Goh, Y., Balasundaram, G., Moothanchery, M., Attia, A., Li, X., Lim, H. Q., Olivo, M., Chan, C. W.

A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study. PLOS ONE, 13(8), 14 pages (2018)
Onishi, H., Udagawa, C., Kubo, M., Nakamura, S., Akashi-Tanaka, S., Kuwayama, T., Zembutsu, H., Chan, C. W.

Ductal carcinoma in-situ arising within benign phyllodes tumours. ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 100(4), E97-E102 (2018)
Lui, S. A., Oh, H. B., Wang, S., & Chan, C. W.

Triple negative breast cancer in Asia: An insider’s view. CANCER TREATMENT REVIEWS, 62, 29-38 (2018)
Wang, C., Kar, S., Lai, X., Cai, W., Arfuso, F., Sethi, G., Kumar, A. P., Chan, C. W.

Significant Effect of Polymorphisms in CYP2D6 on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study. CLINICAL CANCER RESEARCH, 23(8), 2019-2026 (2017)
Zembutsu, H., Nakamura, S., Akashi-Tanaka, S., Kuwayama, T., Watanabe, C., Takamaru, T., Nakamura, Y. , Chan, C. W.

Genomic predictors of neoadjuvant chemotherapy (NACT) response in breast cancer (BC).. In JOURNAL OF CLINICAL ONCOLOGY Vol. 35 (pp. 5 pages). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2017)
Wong, A. L. A., Tan, K. T., Sundar, R., Ow, S., Pang, A., Yap, H. -L., Lee, S. C., Chan, C. W.

Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer. ONCOTARGET, 7(39), 64089-64099 (2016)
Wong, A. L. A., Sundar, R., Wang, T. -T., Ng, T. C., Zhang, B., Tan, S. H., Lee, S. C., Chan, C. W.

High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer. ONCOTARGET, 7(34), 55155-55168 (2016)
Wang, T., Srivastava, S., Hartman, M., Buhari, S. A., Chan, C. W., Iau, P., Lee, S. C.

Considerations regarding lipofilling in patients after breast cancer. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 69(5), E103-E104 (2016)
Chan, C. W.

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. ONCOTARGET, 7(3), 2532-2544 (2016)
Wang, T., Seah, S., Loh, X., Chan, C. W., Hartman, M., Goh, B. C., & Lee, S. C.

Accelerated partial breast irradiation in an Asian population: dosimetric findings and preliminary results of a multicatheter interstitial program. ONCOTARGETS AND THERAPY, 9, 5561-5566 (2016)
Koh, Y. V., Tan, P. W., Buhari, S. A., Iau, P., Chan, C. W., Shen, L., Tang, J. I. H., Chan, C. W.

Genomic landscapes of breast fibroepithelial tumors. NATURE GENETICS, 47(11), 1341-+ (2015)
Tan, J., Ong, C. K., Lim, W. K., Ng, C. C. Y., Thike, A. A., Ng, L. M., Teh, B. T., Chan, C. W.

Cell viability and angiogenic potential of a bioartificial adipose substitute. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 9(6), 702-713 (2015)
Panneerselvan, A., Nguyen, L. T. H., Su, Y., Teo, W. E., Liao, S., Ramakrishna, S., & Chan, C. W.

Differential cell adhesion of breast cancer stem cells on biomaterial substrate with nanotopographical cues.. J Funct Biomater, 6(2), 241-258 (2015)
Tan, K. K. B., Giam, C. S. Y., Leow, M. Y., Chan, C. W., & Yim, E. K. F., Chan, C. W.

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. NATURE GENETICS, 47(4), 373-U127 (2015)
Michailidou, K., Beesley, J., Lindstrom, S., Canisius, S., Dennis, J., Lush, M. J., Easton, D. F., Chan, C. W.

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. HUMAN MOLECULAR GENETICS, 23(22), 6096-6111 (2014)
Milne, R. L., Burwinkel, B., Michailidou, K., Arias-Perez, J. I., Pilar Zamora, M., Menendez-Rodriguez, P., .Easton, D. F., Chan, C. W.

Simvastatin induced apoptosis and suppressed proliferation of breast cancer through deactivating PI3K/Akt/mTOR pathway. In CANCER RESEARCH Vol. 74 (pp. 2 pages). San Diego, CA: AMER ASSOC CANCER RESEARCH (2014)
Wang, T., Seah, S., Chan, C. W., Hartman, M., Dar, N. N. T., Iau, P., Lee, S. C.

Phase II study of neoadjuvant weekly paclitaxel and carboplatin with lapatinib in HER2+breast cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32 (pp. 1 page). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2014)
Wong, A. L. A., Tan, S. H., Soh, I. P. T., Tan, C. S., Lim, Y. W., Pang, A., Lee, S. C., Chan, C. W.

Effect of low-dose, short-course sunitinib (Su) on tumor vasculature and tumor blood flow for enhancement of chemotherapy efficacy in breast cancer.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 32 (pp. 1 page). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2014)
Wong, A. L. A., Sundar, R., Ow, S. G. W., Wang, T. T., Ng, T. -C., Chan, C. W., Lee, S. C.

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. NATURE GENETICS, 45(4), 392-398 (2013)
Garcia-Closas, M., Couch, F. J., Lindstrom, S., Michailidouo, K., Schmidt, M. K., Brook, M. N., Kraft, P., Chan, C. W.

Low-dose, short-course sunitinib may normalize tumor vasculature and improve tumor blood flow to enhance chemotherapy efficacy in breast cancers. In JOURNAL OF CLINICAL ONCOLOGY Vol. 30 (pp. 1 page). Chicago, IL: AMER SOC CLINICAL ONCOLOGY (2012)
Lee, S. -C., Wong, A. L. A., Ng, T. C., Thng, C. H., Wang, T. T., Tiemsim, M. C., Goh, B. C., Chan, C. W.

Extracellular matrix protein expression is associated with chemotherapy resistance in breast cancer. In CANCER RESEARCH Vol. 72 (pp. 1 page). AMER ASSOC CANCER RESEARCH (2012)
Wang, T., Guo, T., Sze, S. K., Hartman, M., Buhari, S. A., Chan, C. W., Lee, S. C.

Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy. ANNALS OF ONCOLOGY22(8), 1748-1754 (2011)
Chuah, B. Y. S., Putti, T., Salto-Tellez, M., Charlton, A., Iau, P., Buhari, S. A., Lee, S. C., Chan, C. W.

A Commentary on Delayed Presentation of Breast Cancer in Singapore. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 12(6), 1635-1639 (2011)
Chang, G., Chan, C. W., & Hartman, M.

Pharmacokinetics and pharmacodynamics of docetaxel with or without ketoconazole modulation in chemonaive breast cancer patients. ANNALS OF ONCOLOGY, 21(11), 2175-2182 (2010)
Lim, Y. -W., Goh, B. C., Wang, L. Z., Tan, S. H., Chuah, B. Y. S., Lim, S. E., Lee, S. C., Chan, C. W.

Autologous fat transfer – a review of the literature with a focus on breast cancer surgery. Journal of Plastic, Reconstructive and Aesthetic Surgery, 61(12), 1438-1448 (2008)
Chan, C. W., McCulley, S. J., & Macmillan, R. D.

Volume displacement techniques and therapeutic mammoplasty: The Nottingham experience. Advances in Breast Cancer, 5(1), 10-12 (2008)
Macmillan, R. D., Chan, C. W., & McCulley, S. J.

A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis. Biochemical Journal, 407(3), 355-362 (2007)
Chan, C. W., Lee, Y. B., Uney, J., Flynn, A., Tobias, J. H., & Norman, M.